Deep epitope-level profiling across the most important antigens from SARS-CoV-2.
As reported in Nature Communications and Cellular & Molecular Immunology our 2-in-1 microarray contains both full-length proteins and peptides spanning the S1 and S2 spike of SARS-CoV-2. This allows analysis of both antibodies binding full-length proteins and determining epitope level granularity across the important ACE2 receptor binding spike. To ensure solubility, the peptide scan utilizes BSA-conjugated overlapping 12-mer peptides covering the entire S1 and S2 spike protein of SARS-CoV-2, the virus that causes pandemic COVID-19 disease. These deep immune profiling details are useful for coronavirus vaccine development, developing therapeutic antibodies, profiling convalescent plasma, and more.