The world’s largest human protein library. Now with SARS-CoV-2.
All of our futures now depend on the human body’s ability to make antibodies to SARS-CoV-2, the virus that causes pandemic COVID-19 disease. And while it is now clear that recovered patients make protective antibodies against the disease – surprisingly it is the sickest patients making the most anti-SARS-CoV-2 IgG antibodies.
The question is…why?
To help researchers answer this urgent question CDI Labs has created SARS-CoV-2 HuProt™: The Human Proteome Microarray with SARS-CoV-2 proteins. SARS-CoV-2 HuProt™ contains >21,000 full-length human proteins and is the most powerful tool ever created for mapping antigen-specific autoimmunity. SARS-CoV-2 HuProt™ microarrays are available for direct purchase or an all-inclusive service. HuProt™ enables multi-isotype serum profiling of antibodies against three-dimensional antigens with a quantitative readout. It’s also useful for testing monoclonal antibodies, proteins, DNA, RNA, and even some small molecules. With SARS-CoV-2 HuProt™, researchers can finally discover new antigen-specific immune responses that accompany different features of SARS-CoV-2 disease progression, clinical trial treatment response, and vaccine development.
Most fluids contain antibodies and we can analyze them (i.e. peripheral serum/plasma, cerebrospinal fluid, tissue lysates, stool, saliva), or in a synthesized sample, for any isotype (i.e. IgM, IgG, IgA, IgD, IgE). Secondary antibody binding is then quantified using fluorescence intensity measurements of features on the array. We’ll provide you with those RAW readouts – and optionally – normalized readouts and group-comparison statistics.
The two SARS-CoV-2 proteins on these arrays are:
SARS-CoV-2 S1 Receptor-Binding Domain: This S1 ACE2 receptor binding spike is essential for entry of the novel coronavirus into human cells. Our S1 matches the sequence published here, is expressed in human cells & has confirmed binding to ACE2.
SARS-CoV-2 Nucleocapsid: The nucleocapsid is the most abundant protein of a coronavirus. This version is purified from E.coli.