Economic screening for antibodies to pandemic SARS-CoV-2 and other closely related viruses.
The SMI Protein Microarray contains 14 identical sub-arrays of full-length viral proteins, each printed in triplicate, and is highly sensitive, detecting as low as 50 pg of anti-S antibody in human serum. The array allows simultaneous detection of IgG and IgM (multiplexing), and provides a clear profile of each patient’s immune response to infection by the three closely-related coronavirus strains and by influenza. The direct comparison of responses to infection from SARS-CoV2, MERS–CoV and SARS-CoV allows false negatives or non-specific binding to be carefully evaluated.
SMI microarray x14 sample layout.
Experimental procedure for serologic antibody detection.
Example data from COVID-19 patient serum versus healthy controls.
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