Introducing SARS-CoV-2 HuProt™: The Novel Coronavirus Microarray
All of our futures now depend on the human body’s ability to make antibodies to SARS-CoV-2, the virus that causes pandemic COVID-19 disease. And while it is now clear that recovered patients make protective antibodies against the disease – surprisingly it is the sickest patients making the most anti-SARS-CoV2 IgG antibodies .
The question is…why?
To help researchers answer this urgent question CDI Labs has created SARS-CoV-2 HuProt™: The Human Proteome Microarray with SARS-CoV-2 proteins. This new product combines >21,000 autologous human proteins with the S1 ACE2-receptor-binding spike & nucleocapsid from the virus that causes pandemic COVID-19 disease. With SARS-CoV-2 HuProt™, researchers can finally discover new antigen-specific immune responses that accompany different features of SARS-CoV-2 disease progression, clinical trial treatment response, and vaccine development.
Inquire here to purchase SARS-CoV-2 HuProt™ microarrays or serum profiling services:
Why might human proteome microarrays with SARS-CoV-2 data be so important? There is evidence that cytokine release syndrome – similar to that seen in severe side effects of cancer immunotherapies – is involved in fatal COVID-19 cases . CDI Labs collaborators at NYU have already demonstrated that similar side effects to cancer immunotherapies can be predicted by autoantibody signatures using HuProt™ arrays . We made SARS-CoV-2 HuProt™ because we believe similar pre-existing autoantibody signatures may determine those most at risk for COVID-19 disease, may play a role in fatal cases, and can help guide clinical studies of COVID-19 treatments and vaccines. We think it’s time to Be Specific™ about COVID-19.
More about SARS-CoV-2 and pandemic COVID-19 disease:
Outbreak of the novel coronavirus (SARS-CoV-2) began in Wuhan China in late 2019 . Novel coronavirus disease (COVID-19) is the symptomatic presentation of SARS-CoV-2 and presents with a diverse set of systemic and respiratory disorders including fever, cough, sore throat, fatigue, pneumonia with ground-glass opacities, acute cardiac injury, and respiratory distress . Patients, particularly older men and people with underlying inflammatory conditions such as obesity, cardiovascular disease, COPD, and diabetes, are at higher risk of severe COVID-19 and death . However, it is estimated that as many as 86% of SARS-CoV-2 infections are asymptomatic and do not result in COVID disease . The particular reasons for this likely lie in the underlying immunologic response of the infected patients – but the reasons for this remain unclear. With SARS-CoV-2 HuProt™ Microarrays – these questions can now be answered.
More about SARS-CoV-2 HuProt™ Microarrays and Array Analysis Services:
SARS-CoV-2 HuProt™ Microarrays are available for direct purchase or an all-inclusive service. These arrays contain >21,000 full-length human proteins + the most important two SARS-CoV-2 proteins and is the most powerful tool ever created for mapping antigen-specific immunity. HuProt™ enables multi-isotype serum profiling of antibodies against three-dimensional antigens with a quantitative readout. It’s also useful for testing monoclonal antibodies, proteins, DNA, RNA, and even some small molecules.
The two SARS-CoV-2 proteins on these arrays are:
SARS-CoV-2 S1 Receptor-Binding Domain: This S1 ACE2 receptor binding spike is essential for entry of the novel coronavirus into human cells. Our S1 matches the sequence published here , is expressed in human cells, & has confirmed binding to ACE2.
SARS-CoV-2 Nucleocapsid: The nucleocapsid is the most abundant protein of a coronavirus. This version is purified from E.coli.
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