HuProt: The Human Proteome Microarray

There have been other protein microarrays, but none were made from a protein library as comprehensive or thoroughly validated as HuProt. HuProt arrays allow for pan-isotype autoantibody biomarker profiling versus properly folded, three-dimensional human proteins.

HuProt: The Human Proteome Microarray

There have been other protein microarrays, but none were made from a protein library as comprehensive or thoroughly validated as HuProt. HuProt arrays allow for pan-isotype autoantibody biomarker profiling versus properly folded, three-dimensional human proteins.

The world’s largest human protein library on a slide.

HuProt™: The Human Proteome Array contains >21,000 full-length human proteins and is the most powerful tool ever created for mapping antigen-specific immunity.

Most fluids contain antibodies and we can analyze them (i.e. peripheral serum/plasma, cerebrospinal fluid, tissue lysates, stool, saliva), or in a synthesized sample, for any isotype (i.e. IgM, IgG, IgA, IgD, IgE). Secondary antibody binding is then quantified using fluorescence intensity measurements of features on the array. We’ll provide you with those RAW readouts – and optionally – normalized readouts and group-comparison statistics.

There’s more to HuProt than serum profiling.  We’ve profiled nucleotide binding, antibody specificity, small molecule binding, protein-protein interactions, and more. If you can dream up a study, we can help you get it done.  Dozens of academic papers have been published on HuProt, demonstrating the importance of antigen-specific immunity for everything from Alzheimers to lupus to cancer. We’ve even helped predict side-effects to immuno-oncology drugs prior to treatment. See more here.

Contact us to learn more.