The Story of VirD™ — Embedded Membrane Proteins by Virion Display
Virion Display (VirD) is our novel microarray that uses virions to display functional membrane proteins. It can be scaled or tailored for different modalities including high-content, high-throughput platforms for screening ligands and drugs of human membrane proteins against drug-relevant targets such as GPCRs, immune checkpoints, and neuronal receptors.
In 2019, Guan-Da Syu, et al created the first VirD-Human G protein-coupled receptor (GPCR) array, or VirD-GPCR array, which contains 315 properly folded, non-olfactory GPCRs. This work demonstrated that the embedded membrane proteins on VirD arrays retain proper folding and normal biochemical interactions; the membrane proteins in these arrays retained a wide variety of normal functions including antibody staining, lectin binding, and ligand binding. The VirD array platform holds tremendous potential for high-throughput screening for novel drugs, affinity reagents, and natural ligands.